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KMID : 0378019600030060065
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New Medical Journal
1960 Volume.3 No. 6 p.65 ~ p.72
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The Changes of the Blood and Adrenal Cortex in the Experimental Traumatic Shock
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Abstract
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It is generally accepted that primary shock develops immediately after the injury accompanied by hemodilution, and the fetal cases with primary shock may have resulted from adrenal cortical deficiency. Kim in our laboratory reported that the strong acceleration of blood coagulation occured after the injury in the experimental study. Y. K. Kim in our laboratory also confirmed that in the shocked animal by electic stream, the acceleration of blood coagulation,
the increase of total cholesterol and phospholipid in the serum and histochemical diminution of lipids in the adrenal cortex went to pararell.
So author intended to confirm whether such facts as above mentioned might appear also in the severe injured animal or not.
Method and materials.
Animals were rabbits weighing about 2kg, more or less.
Injury was done by hammer in The legs. The bone including soft tissue were crushed. The determination of blood coagulation was done by LeeWhite´s method.
The other observations in the blood were
the red cell count, and the hematocrit, paper electrophoresis, total cholesterol of the serum. Histological study was done in the adrenal cortex:HE staining, Sudan III hydrosol method, and Baker test.
The results were as follows
1. --Hemodilution.
2. Strong acceleration of blood coagulation.
3. Decrease of the R. B. C., W. B. C., platelet, Hb. and albumin.
4. Increase of total cholesterol in the serum.
5. Narrowing of zona fasciculata marked appearing of vacuolized cells and focal necrotic lesion in the zona fasciculata of adrenal cortex.
6. Diminishing of lipids in the zona fasciculata, especially in the outer zone of the adrenal cortex.
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KEYWORD
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